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広島工業大学
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平賀 良知 (ヒラガ ヨシカズ,HIRAGA Yoshikazu)

基本情報 研究分野 研究業績

 

著書
No.著書名(タイトル) URL, 担当区分, 出版社, 出版年月(日), 担当範囲, ISBN 
1
生物工学とケミカルバイオロジー , , 生物工学, 2013年09月25日, ,  
2
どれが本物? 単離された化合物は“天然物”が“アーティファクト”か , , 化学同人, 2010年10月31日, ,  
3
Biosynthesis of monoterpenoids in higher plants: Mechanisms of chain elongation and chiral center generation , 共著, Kodansha, 1997年01月, ,  

 

報告書等
No.報告書等名(MISCタイトル) URL, 誌名, 巻( 号), 開始ページ- 終了ページ, 出版年月(日) 
1
Plant-Growth-Inhibition Active Oligomeric Proanthocyanidins from the Root-Stalks of Dicranopteris pedata , Journal of Kibi International University School of Social Welfare, 6,  89- 96, 2001年03月 
2
Reactions of C10-acyclic allylic esters with divalent metal ions , Journal of Science of the Hiroshima University, Series A: Physics and Chemistry, 58( 1), 235- 245, 1994年01月 
3
Conformation of geranyl diphosphate-manganese(II) complex as studied by proton and phosphorus relaxation measurements. , Journal of Science of the Hiroshima University, Series A: Physics and Chemistry, 58( 1), 247- 258, 1994年01月 
4
Reactions of acyclic allylic diphosphates with divalent metal ions directed toward biosynthetic studies of cyclic monoterpenoid , Journal of Science of the Hiroshima University, Series A: Physics and Chemistry, 55( 1), 1- 15, 1991年01月 

 

学術論文
No.論文タイトル(題目) URL, 誌名(出版物名), 巻( 号), 開始ページ- 終了ページ, 出版年月(日), DOI 
1
Neural dysfunctions following experimental permanent occlusions of bilateral common carotid arteries cause an increase of rat voluntary alcohol drinking behavior , Legal Medicine, 51,  101875-1- 101875-9, 2021年04月, https://doi.org/10.1016/j.legalmed.2021.101875 
2
Combined Drug Resistance Mutations Substantially Enhance Enzyme Production in Paenibacillus agaridevorans , Journal of Bacterilogy, 200( 17), e00188-18-1- e00188-18-17, 2018年09月,  
3
13C NMR Spectroscopic Studies of the Behaviors of Carbonyl Compounds in Various Solutions. , Tetrahedron Letters, 58( 50), 4677- 4681, 2017年11月,  
4
Metabolic Perturbation to Enhance Polyketide and Nonribosomal Peptide Antibiotic Production using Triclosan and Ribosome-targeting Drugs , Applied Microbiology and Biotechnology, 101( 10), 4417- 4431, 2017年03月,  
5
Formation of Isomerized E,Z-Configured 1,3-Dienes in Construction of Macrocyclic Trienes by Diene-Ene RCM , Bulletin Chemical Society of Japan, 88( 1), 146- 148, 2015年01月,  
6
Marangoni flow around a camphor disk regenerated by the interaction between camphor and sodium dodecyl sulfate molecules. , Colloids and Surfaces A: Physicochemical and Engineering Aspects, 466,  40- 44, 2015年01月,  
7
A novel non-metathetic behavior of Grubbs catalyst: Ruthenium-mediated intramolecular [3 + 2] cycloaddition of bis-1,3-dienes. , Journal of Organometalic Chemistry, 273( 1), 171- 175, 2013年01月,  
8
Stereochemical deuterium‐labeling study on the denitrogenation of 7,7-diethoxy-2,3-diazabicyclo[2.2.1]hept-2-ene. , Journal of Physical Organic Chemistry, 24( 10), 894- 901, 2011年06月,  
9
Hydroxy-group effect on the regioselectivity in a photochemical oxetane formation reaction (the Paternò-Büchi Reaction) of geraniol derivatives , Photochemical and Photobiological Sciences, 10,  1469- 1473, 2011年05月, https://doi.org/10.1039/C1PP05056G 
10
Cooperative effect of a hydroxyl and carboxyl group on the catalytic ability of novel b-homoproline derivatives in the direct asymmetric aldol reactions. , Tetrahedron: Asymmetry, 22( 2), 226- 237, 2011年03月,  
11
Concentration and temperature dependency of regio- and stereoselectivity in a photochemical [2+2] cycloaddition reaction (the Paternò–Büchi Reaction): Origin of the hydroxy-group directivity. , Journal of the American Chemical Society, 133( 8), 2592- 2604, 2011年02月,  
12
Formation of macrocyclic lactones in the Paternò–Büchi dimerization reaction. , Beilstein Journal of Organic Chemistry, 7,  265- 269, 2011年02月,  
13
Novel cyclic -aminophosphonate derivatives as an efficient organocatalyst for the asymmetric Michael addition reactions of ketones to nitrostyrenes. , Tetrahedron: Asymmetriy, 21( 15), 1861- 1868, 2010年07月,  
14
Contribution of 1,2-dihydroxy-5-(methylsulfinyl)pentan-3-one (DMTS-P1) to the formation of dimethyl trisulfide (DMTS) during the storage of Japanese sake. , Journal of Agricaltural and Food Chemistry, 58( 13), 7756- 7761, 2010年06月,  
15
Screening and Identification of Precursor Compounds of Dimethyl Trisulfide (DMTS) in Japanese Sake , Journal of Agricaltural and Food Chemistry, 57( 1), 189- 195, 2009年02月,  
16
Site- and stereoselectivity in the photochemical oxetane formation reaction (Paternò–Büchi reaction) of tetrahydrobenzofuranols with benzophenone: Hydroxy-directed diastereoselectivity? , Chemistry Letters, 37( 8), 822- 823, 2008年08月,  
17
Three new glycolipids with cytolytic activity from cultured marine dinoflagellate Heterocapsa circularisquama , Natural Product Research, 22( 8), 649- 657, 2008年05月,  
18
Miltiple functions of ergosterol in the fission yeast Schizosaccharocyces pombe , Microbiology, 154( 3), 830- 841, 2008年03月,  
19
Influence of co-solvents in the highly efficient selective monohydrolysis of a symmetric diester. , Tetrahedron Letters, 48( 26), 8508- 8510, 2007年09月,  
20
Studies on ring-closing metathesis for the formation of the 11 membered ring system of daphnezomine C , Bulletin of the Chemical Society of Japan, 80( 8), 1597- 1604, 2007年08月,  
21
A new method for isolation of S-adenosylmethonine (SAM)-accumulationg yeast , Applied Microbiology and Biotechnology, 69( 6), 704- 710, 2006年06月,  
22
Temperature-dependence of enantioselectivity and desymmetrization in the acetylation of 2-mono- and 2,2-di-substituted 1,3-propanediols by a novel lipase isolated from yeast Cryptococcus spp. S-2 , Biocatalysis and Biotransformation, 24( 5), 390- 395, 2006年05月,  
23
Two-parameter analysis of solvent effects on selectivity in chemical reactions: Information of polarity and activation volume at the transition state in organic and enzymatic reactions , Chemistry Letters, 35( 2), 208- 209, 2006年02月,  
24
Comparison of the chiral recognition of prochiral substrates in the acetylation reaction by a novel lipase (CSL) from the yeast, Cryptococcus spp. S-2 with immobilized PPL. Enzyme-catalyzed desymmetrization and asymmetrization of prochiral 2,2-disubstituted 1,3-propanediols by CSL and immobilized PPL. , Journal of Molecular Catalysis. B, Enzymatic, 38( 1), 1- 10, 2006年01月,  
25
1H and 13C NMR spectroscopic studies of half-esters from monohydrolysis of dialkyl bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylates. , Spectroscopy, 18( 3), 469- 483, 2004年09月,  
26
Relationship between hydrophobicity of dipeptides and Michaelis-Menten constant Km of their enzymatic hydrolysis , Bulletin of the Chemical Society of Japan, 77( 6), 1187- 1193, 2004年06月, 10.1246/bcsj.77.1187 
27
New exo/endo selectivity observed in monohydrolysis of dialkyl bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylates. , Tetrahedron Letters, 44( 47), 8567- 8570, 2003年09月, 10.1016/j.tetlet.2003.09.131 
28
Sterol composition of a cultured marine dinoflagellate, Heterocapsa circularisquama. , Natural Product Research, 17( 4), 263- 267, 2003年04月, 10.1080/1057563021000060130 
29
A new digalactosyl diacylglycerol from a cultured marine dinoflagellate Heterocapsa circularisquama. , Journal of Natural Products, 65( 10), 1494- 1496, 2002年10月, 10.1021/np0201265 
30
Hydrophobicity and structure of 1,2,4-triazole derivatives bearing 1-carbamoyl and 3-sulfonyl groups. , Bulletin of the Chemical Society of Japan, 75( 3), 567- 574, 2002年03月, 10.1246/bcsj.75.567 
31
Stereochemical considerations on the stereoselective cyclopropanation reactions of 3-aryl-2-phosphonoacrylates induced by the (-)-8-phenylmenthyl group as a chiral auxiliary. , Journal of the Chemical Society, Perkin Transactions 1, ( 2), 179- 190, 2002年02月, 10.1039/b108925k 
32
Purification and characterization of a O-methyltransferase capable of methylating 2-hydroxy-3-alkylpyrazine from Vitis vinifera L. (cv. Cabernet Sauvignon). , Bioscience, Biotechnology, and Biochemistry, 65( 10), 2213- 2219, 2001年10月, 10.1271/bbb.65.2213 
33
Benzoxazinoid glucosides from Acanthus ilicifolius , Phytochemistry, 58( 4), 637- 640, 2001年10月, 10.1016/S0031-9422(01)00267-9 
34
Megastigmane and iridoid glucosides from Clerodendrum inerme. , Phytochemistry, 58( 2), 333- 336, 2001年09月, 10.1016/S0031-9422(01)00208-4 
35
Kinetic evidence for the hydrophobic atmosphere of the catalytic cavity in carboxypeptidase Y based on a linear relationship between Michaelis-Menten constant Km and hydrophobicity of the substrates. , Chemistry Letters, ( 5), 418- 419, 2001年05月, 10.1246/cl.2001.418 
36
Lignan glucosides from Acanthus ilicifolius , Phytochemistry, 56( 4), 369- 372, 2001年02月, 10.1016/S0031-9422(00)00362-9 
37
Canthin-6-one and beta-carboline alkaloids from Eurycoma harmandiana , Phytochemistry, 56( 4), 383- 386, 2001年02月, 10.1016/S0031-9422(00)00363-0 
38
Synthesis of hippospongic acid A analogues designed for investigating the structure-activity relationship of its biological activity , Australian Journal of Chemistry, 53( 11/12), 909- 912, 2000年12月, 10.1071/CH00101 
39
The Julia-Colonna asymmetric epoxidation reaction of chalcone catalyzed by length defined oligo-L-leucine: Importance of the N-terminal functional group and helical structure of the catalyst in the asymmetric induction. , Bulletin of the Chemical Society of Japan, 73( 9), 2115- 2121, 2000年09月, 10.1246/bcsj.73.2115 
40
Ion-transport activity of phenylpentanoic acids occurring in the roots of Athyrium yokoscense. , Bioscience, Biotechnology, and Biochemistry, 63( 5), 958- 960, 1999年05月, 10.1271/bbb.63.958 
41
Synthesis of rac-hippospongic acid A and revision of the structure. , Journal of the Chemical Society, Perkin Transactions 1, ( 4), 489- 496, 1999年04月,  
42
Selective Ring-expansion of Oxirane into Tetrahydropyran and Tetrahydrofuran by Reagent-controlled Conditions. , Journal of Chemical Research, ( 9), 500- 501, 1998年09月, 10.1039/a803552k 
43
Allelopathic substances in ferns. , Recent Research Developments in Phytochemistry, 2,  429- 454, 1998年07月,  
44
Stereoselective syntheses of (+)-rhopaloic acid A and (-)-ent- and (±)-rac-rhopaloic acid A , Journal of the Chemical Society, Perkin Transactions 1, ( 5), 925- 934, 1998年05月,  
45
Asymmetric induction in Darzens condensation by means of (-)-8-phenylmenthyl and (-)-menthyl auxiliaries. , Journal of the Chemical Society, Perkin Transrations 1, ( 4), 689- 698, 1998年04月,  
46
Evidence for biosynthetic meta-hydroxylation of benzoic acid by means of isolation of only meta-functionalized phenylpentanoic acids from Athyrium yokoscense. , Natural Product Letters, 11( 3), 187- 192, 1998年03月,  
47
3-Hydroxy-5,6-epoxy-b-ionone as germination inhibitory active constituent in Athyrium yokoscense. , Natural Product Letters, 12( 1), 35- 40, 1998年01月, 10.1080/10575639808048868 
48
Selective conversion of bromo oxirane into tetrahydropyranylacrylate by epoxide ring opening , Journal of the Chemical Society, Chemical Communications, ( 9), 875- 876, 1997年09月, 10.1039/a700788d 
49
Biologically active clerodane-type diterpene glycosides from the root-stalks of Dicranopteris pedata. , Phytochemistry, 46( 5), 839- 844, 1997年05月, 10.1016/S0031-9422(97)00377-4 
50
(-)-Loliolide and other germination inhibitory active constituents in Equisetum arvense. , Natural Product Letters, 10( 1), 181- 186, 1997年01月,  
51
Yeast homolog of nonspecific lipid-transfer protein (sterol carrier protein 2) may be a stress protein in peroxisomes , Annals of the New York Academy of Sciences, 804,  687- 690, 1996年12月, 10.1111/j.1749-6632.1996.tb18668.x 
52
Hippospongic acid A: an unusual triterpenoic acid from a marine sponge, Hippospongia sp., which inhibits gastrulation of starfish embryos , Tetrahedron Letters, 37( 43), 7765- 7766, 1996年10月, 10.1016/0040-4039(96)01772-8 
53
Asymmetric Darzens condensation of ketones with a-chloroacetates by means of (-)-8-phenylmenthyl auxiliary , Journal of the Chemical Society, Chemical Communications, ( 21), 2411- 2412, 1996年10月, 10.1039/cc9960002411 
54
Rhopaloic acid A: a novel norsesterterpene from a marine sponge, Rhopaloeides sp., which inhibits gastrulation of starfish embryos. , Tetrahedron Letters, 37( 13), 2265- 2266, 1996年05月, 10.1016/0040-4039(96)00271-7 
55
24-Epi-pterosterone: a novel phytoecdysone from the roots of Athyrium yokoscense. , Phytochemistry, 41( 3), 745- 747, 1996年03月, 10.1016/0031-9422(95)00688-5 
56
Structure-activity relationships of cinnamic acid derivatives as germination inhibitor of the fern Gleichenia japonica. , Natural Product Letters, 9( 1), 21- 26, 1996年01月, 10.1080/10575639608043573 
57
Near-stoichiometric interaction between the non-specific lipid-transfer protein of the yeast Candida tropicalis and peroxisomal acyl-coenzyme A oxidase prevents the thermal denaturation of the enzyme in vitro. , Yeast, 10( 11), 1467- 1476, 1994年11月, 10.1002/yea.320101110 
58
13C NMR detection of delocalized C10-allylic cation in the biosynthesis of farnesyl diphosphate. , Journal of the Chemical Society, Chemical Communications, ( 9), 1057- 1058, 1994年05月, 10.1039/c39940001057 
59
Facile synthesis of (4S)-(-)-[9-3H]limonene , Journal of Labelled Compounds and Radiopharmaceuticals, 33( 8), 733- 737, 1993年08月, 10.1002/jlcr.2580330809 
60
Biosynthetic generation of the species-specific chirality of limonene in Mentha spicata and Citrus unshiu , Journal of the Chemical Society, Chemical Communications, ( 17), 1370- 1372, 1993年04月, 10.1039/c39930001370 
61
Regioselective hydrogen elimination from the 10-methyl group of geranyl diphosphate in the biological formation of the 8(9)-double bond of limonene , Journal of the Chemical Society, Chemical Communications, ( 21), 1556- 1558, 1992年11月, 10.1039/c39920001556 
62
Synthesis of [10,10,10-2H3]Geranyl Diphosphate , Journal of Labelled Compounds and Radiopharmaceuticals, 29( 5), 591- 597, 1991年05月, 10.1002/jlcr.2580290511 
63
Facile synthesis of regioselectively deuterated (3R)-(-)-[8,8,8-2H3]linalool , Chemistry Letters, ( 1), 49- 52, 1991年01月, 10.1246/cl.1991.49 
64
The biosynthesis of isoprenoids in higher plants. V. Biosynthesis of cyclic monoterpenoids. The role of bivalent metal cations in the cyclization of acyclic allylic diphosphates. , 日本化学会誌, ( 4), 629- 634, 1988年04月, 10.1246/nikkashi.1988.629 
65
Biosynthesis of Cyclic Monoterpenoids. Involvement of Stereochemically Specified Linalyl Cation in the Cyclization of C10-Prenyl Chain , Chemistry Letters, ( 1), 115- 118, 1988年01月, 10.1246/cl.1988.115